Wyandotte County is now under a tornado warning.
Residents are advised to take cover.
At 6:31 p.m., a confirmed large and destructive tornado was observed over Eudora, or 7 miles east of Lawrence, moving northeast at 45 mph, the weather service said.
Bonner Springs, Edwardsville and Kansas City, Kansas, are in the path of the tornado.
For more information, visit www.weather.gov.